*Correspondence: Giulia Guerriero, Department of Biology, Comparative Endocrinology Lab, Universit degli Studi di Napoli Federico II, Via Mezzocannone, 8, Naples 80134, Italy e-mail: [email protected] This article was submitted to Experimental Endocrinology, a section of the journal Frontiers in Endocrinology
305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages
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These concentrations were determined by the lethal concentration
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